Flavonoids, proanthocyanidins, and the risk of stomach cancer.
Identifieur interne : 002634 ( Main/Exploration ); précédent : 002633; suivant : 002635Flavonoids, proanthocyanidins, and the risk of stomach cancer.
Auteurs : Marta Rossi [Italie] ; Valentina Rosato ; Cristina Bosetti ; Pagona Lagiou ; Maria Parpinel ; Paola Bertuccio ; Eva Negri ; Carlo La VecchiaSource :
- Cancer causes & control : CCC [ 1573-7225 ] ; 2010.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Boissons, Comportement alimentaire, Femelle, Flavonoïdes, Fruit, Humains, Italie (épidémiologie), Jeune adulte, Légumes, Modèles logistiques, Mâle, Odds ratio, Proanthocyanidines, Risque, Régime alimentaire, Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs de l'estomac (), Tumeurs de l'estomac (épidémiologie), Tumeurs de l'estomac (étiologie), Études cas-témoins.
- MESH :
- épidémiologie : Italie, Tumeurs de l'estomac.
- étiologie : Tumeurs de l'estomac.
- Adulte, Adulte d'âge moyen, Boissons, Comportement alimentaire, Femelle, Flavonoïdes, Fruit, Humains, Jeune adulte, Légumes, Modèles logistiques, Mâle, Odds ratio, Proanthocyanidines, Risque, Régime alimentaire, Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs de l'estomac, Études cas-témoins.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Beverages, Case-Control Studies, Diet, Feeding Behavior, Female, Flavonoids, Fruit, Humans, Italy (epidemiology), Logistic Models, Male, Middle Aged, Odds Ratio, Proanthocyanidins, Risk, Stomach Neoplasms (epidemiology), Stomach Neoplasms (etiology), Stomach Neoplasms (prevention & control), Vegetables, Young Adult.
- MESH :
- chemical : Flavonoids, Proanthocyanidins.
- epidemiology : Italy, Stomach Neoplasms.
- etiology : Stomach Neoplasms.
- prevention & control : Stomach Neoplasms.
- Adult, Aged, Aged, 80 and over, Beverages, Case-Control Studies, Diet, Feeding Behavior, Female, Fruit, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Risk, Vegetables, Young Adult.
Abstract
Flavonoids have been suggested to be responsible for the potential beneficial properties of fruit and vegetables on stomach cancer risk. To provide further information on flavonoids, proanthocyanidins, and gastric cancer risk, we analyzed data from a case-control study conducted in Italy. Subjects were 230 cases with incident, histologically confirmed gastric cancer and 547 frequency-matched controls, admitted to the same hospitals of cases for acute, non-neoplastic conditions. Subjects were interviewed using a reproducible and valid food frequency questionnaire. We estimated the odds ratios (ORs) of gastric cancer and their corresponding 95% confidence intervals (CIs) using unconditional logistic regression models including terms for major recognized gastric cancer risk factors. The ORs of the highest quintile of intake compared to the lowest were below unity for all classes of flavonoids, in the absence, however, of significant associations. Strong inverse relations were found for proanthocyanidins. The OR was 0.44 (95% CI, 0.25-0.76) for monomers and dimers combined and 0.36 (95% CI, 0.21-0.63) for polymers with three or more mers. Further adjustment for fruit and vegetables, or vitamin C, did not materially change these associations. This is the first epidemiological study to suggest that dietary proanthocyanidins have a favorable role on gastric cancer risk.
DOI: 10.1007/s10552-010-9588-4
PubMed: 20521092
Affiliations:
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Le document en format XML
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Bosetti</name></author><author><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name></author><author><name sortKey="Parpinel, Maria" sort="Parpinel, Maria" uniqKey="Parpinel M" first="Maria" last="Parpinel">Maria Parpinel</name></author><author><name sortKey="Bertuccio, Paola" sort="Bertuccio, Paola" uniqKey="Bertuccio P" first="Paola" last="Bertuccio">Paola Bertuccio</name></author><author><name sortKey="Negri, Eva" sort="Negri, Eva" uniqKey="Negri E" first="Eva" last="Negri">Eva Negri</name></author><author><name sortKey="La Vecchia, Carlo" sort="La Vecchia, Carlo" uniqKey="La Vecchia C" first="Carlo" last="La Vecchia">Carlo La Vecchia</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20521092</idno><idno type="pmid">20521092</idno><idno type="doi">10.1007/s10552-010-9588-4</idno><idno 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Rossi</name><affiliation wicri:level="3"><nlm:affiliation>Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. mrossi@marionegri.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche Mario Negri, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Rosato, Valentina" sort="Rosato, Valentina" uniqKey="Rosato V" first="Valentina" last="Rosato">Valentina Rosato</name></author><author><name sortKey="Bosetti, Cristina" sort="Bosetti, Cristina" uniqKey="Bosetti C" first="Cristina" last="Bosetti">Cristina Bosetti</name></author><author><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name></author><author><name sortKey="Parpinel, Maria" sort="Parpinel, Maria" uniqKey="Parpinel M" first="Maria" last="Parpinel">Maria Parpinel</name></author><author><name sortKey="Bertuccio, Paola" sort="Bertuccio, Paola" uniqKey="Bertuccio P" first="Paola" last="Bertuccio">Paola Bertuccio</name></author><author><name sortKey="Negri, Eva" sort="Negri, Eva" uniqKey="Negri E" first="Eva" last="Negri">Eva Negri</name></author><author><name sortKey="La Vecchia, Carlo" sort="La Vecchia, Carlo" uniqKey="La Vecchia C" first="Carlo" last="La Vecchia">Carlo La Vecchia</name></author></analytic><series><title level="j">Cancer causes & control : CCC</title><idno type="eISSN">1573-7225</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Beverages</term><term>Case-Control Studies</term><term>Diet</term><term>Feeding Behavior</term><term>Female</term><term>Flavonoids</term><term>Fruit</term><term>Humans</term><term>Italy (epidemiology)</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Proanthocyanidins</term><term>Risk</term><term>Stomach Neoplasms (epidemiology)</term><term>Stomach Neoplasms (etiology)</term><term>Stomach Neoplasms (prevention & control)</term><term>Vegetables</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Boissons</term><term>Comportement alimentaire</term><term>Femelle</term><term>Flavonoïdes</term><term>Fruit</term><term>Humains</term><term>Italie (épidémiologie)</term><term>Jeune adulte</term><term>Légumes</term><term>Modèles logistiques</term><term>Mâle</term><term>Odds ratio</term><term>Proanthocyanidines</term><term>Risque</term><term>Régime alimentaire</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs de l'estomac ()</term><term>Tumeurs de l'estomac (épidémiologie)</term><term>Tumeurs de l'estomac (étiologie)</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Flavonoids</term><term>Proanthocyanidins</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Italy</term><term>Stomach Neoplasms</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Stomach Neoplasms</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Stomach Neoplasms</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Italie</term><term>Tumeurs de l'estomac</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Tumeurs de l'estomac</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Beverages</term><term>Case-Control Studies</term><term>Diet</term><term>Feeding Behavior</term><term>Female</term><term>Fruit</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Risk</term><term>Vegetables</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Boissons</term><term>Comportement alimentaire</term><term>Femelle</term><term>Flavonoïdes</term><term>Fruit</term><term>Humains</term><term>Jeune adulte</term><term>Légumes</term><term>Modèles logistiques</term><term>Mâle</term><term>Odds ratio</term><term>Proanthocyanidines</term><term>Risque</term><term>Régime alimentaire</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs de l'estomac</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Flavonoids have been suggested to be responsible for the potential beneficial properties of fruit and vegetables on stomach cancer risk. To provide further information on flavonoids, proanthocyanidins, and gastric cancer risk, we analyzed data from a case-control study conducted in Italy. Subjects were 230 cases with incident, histologically confirmed gastric cancer and 547 frequency-matched controls, admitted to the same hospitals of cases for acute, non-neoplastic conditions. Subjects were interviewed using a reproducible and valid food frequency questionnaire. We estimated the odds ratios (ORs) of gastric cancer and their corresponding 95% confidence intervals (CIs) using unconditional logistic regression models including terms for major recognized gastric cancer risk factors. The ORs of the highest quintile of intake compared to the lowest were below unity for all classes of flavonoids, in the absence, however, of significant associations. Strong inverse relations were found for proanthocyanidins. The OR was 0.44 (95% CI, 0.25-0.76) for monomers and dimers combined and 0.36 (95% CI, 0.21-0.63) for polymers with three or more mers. Further adjustment for fruit and vegetables, or vitamin C, did not materially change these associations. This is the first epidemiological study to suggest that dietary proanthocyanidins have a favorable role on gastric cancer risk.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><noCountry><name sortKey="Bertuccio, Paola" sort="Bertuccio, Paola" uniqKey="Bertuccio P" first="Paola" last="Bertuccio">Paola Bertuccio</name><name sortKey="Bosetti, Cristina" sort="Bosetti, Cristina" uniqKey="Bosetti C" first="Cristina" last="Bosetti">Cristina Bosetti</name><name sortKey="La Vecchia, Carlo" sort="La Vecchia, Carlo" uniqKey="La Vecchia C" first="Carlo" last="La Vecchia">Carlo La Vecchia</name><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name><name sortKey="Negri, Eva" sort="Negri, Eva" uniqKey="Negri E" first="Eva" last="Negri">Eva Negri</name><name sortKey="Parpinel, Maria" sort="Parpinel, Maria" uniqKey="Parpinel M" first="Maria" last="Parpinel">Maria Parpinel</name><name sortKey="Rosato, Valentina" sort="Rosato, Valentina" uniqKey="Rosato V" first="Valentina" last="Rosato">Valentina Rosato</name></noCountry><country name="Italie"><region name="Lombardie"><name sortKey="Rossi, Marta" sort="Rossi, Marta" uniqKey="Rossi M" first="Marta" last="Rossi">Marta Rossi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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